Ketomar.......(Ketotifen)

Ketomar (Ketotifen)

Therapeutic Group: Anti Histamine

Presentation

Ketomar Tablet: Each tablet contains Ketotifen Fumarate BP 1.38 mg equivalent to Ketotifen 1 mg.

Ketomar Syrup: Each 5 ml syrup contains Ketotifen Fumarate BP 1.38 mg equivalent to Ketotifen 1 mg.

Descriptions

Ketotifen is a nonbronchodilator anti-asthmatic drug which inhibits the effects of certain endogenous substances known to be inflammatory mediators. In addition, Ketotifen is a potent anti-allergic substance possessing a powerful and sustained noncompetitive histamine (H1) receptor blocking property.



Ketotifen is a type of asthma medication which, when taken every day and used along with other anti-asthmatic medications, may reduce the frequency, severity and duration of asthma symptoms or attacks in patients. It may also lead to a reduction in daily requirements of other anti-asthmatic medications such as Theophyllines and b2-agonists, without the deterioration in pulmonary functions (FEV1, FVC and PEFR). The prophylactic activity of Ketotifen may take several weeks to become fully established. Ketotifen will not abort established attacks of asthma.

Indications

- Prophylactic treatment of bronchial asthma

- Allergic rhinitis

- Allergic conditions such as hay fever, itchy rash or reactions to insect bites.

- Allergic conjunctivitis

Dosage & Administration

Tablet and syrup

(Ketotifen may be taken with or without food)

Ketomar Tablet:

Above 3 years and Adults:
1 mg twice daily (once in the morning & once in the evening.

Elderly Same as adult dose or as advised by the physician.

Ketomar Syrup:
6 months to 3 years:
0.25 ml / kg body weight, twice daily (Once in the morning & once in the evening).

* Missed dose- If a dose of this medicine is missed that should be taken as soon as possible. However, if it is almost time for the next dose, skip the missed dose and the regular dosing schedule should be maintained. Dose should not be doubled in case of a missed dose.

Side Effects

Drowsiness, and in isolated cases dry mouth and slight dizziness may occur at the beginning of treatment but usually disappear spontaneously after a few days.

Precautions

Symptomatic and prophylactic anti-asthmatic drugs (Xanthine derivatives, b2-agonists, Sodium Cromoglycate, Corticosteroids) already in use should not be reduced immediately when treatment with Ketotifen is initiated. This applies especially to Systemic Corticosteroids and ACTH injections because of the possible existence of adrenocortical insufficiency in steroid-dependent patients. During the first day of treatment with Ketotifen, reactions may be impaired and patients should be warned not to take charge of vehicle or machinery until the effect of Ketotifen treatment on the individual is known.

Contraindications

Hypersensitivity to Ketotifen or any other components of the formulation.

Use in Pregnancy & Lactation

Pregnancy: Its safety in human pregnancy has not been established. Ketotifen should therefore be given to pregnant women only in compelling circumstances.

Lactation: Ketotifen is excreted in breast milk. Therefore mothers receiving Ketotifen should not breast-feed.

Drug Interaction

A reversible fall in the thrombocyte count in patients receiving Ketotifen concomitantly with oral anti-diabetic agents has been observed in rare cases. So it has been suggested that this combination should therefore be avoided.
Ketotifen may potentiate the effects of sedatives, hypnotics, anti-histamines and alcohol.

Overdose

The reported features of over dosage include confusion, drowsiness, disorientation, headache, bradycardia and respiratory depression. Elimination of the drug with gastric lavage or emesis is recommended. Otherwise general supportive treatment is all that is required shall be instituted.

Commercial Packaging

Ketomar Tablet: Each box contains 10 blister strips of 10 tablets.
Ketomar Syrup: 100 ml syrup in amber glass bottle with measuring cup

Visral.... Tiemonium Methylsulfate

Visral

Visral may be available in the countries listed below.

Ingredient matches for Visral

Tiemonium Methylsulfate

Tiemonium Methylsulfate is reported as an ingredient of Visral in the following countries:

• Bangladesh

Encilor ..........(Loratadine)

Encilor (Loratadine)

Therapeutic Group: Anti Histamine

Presentation

Encilor : Each tablet contains Loratadine INN 10 mg.

Descriptions

Encilor tablet is a preparation of Loratadine. Loratadine is a non-sedative histamine H1-receptor antagonist with antiallergic properties. Loratadine is a long acting tricyclic antihistamine with selective peripheral H1-receptor antagonistic activity and no central sedative or anticholinergic effect. It is rapidly effective and long-lasting, allowing once-a-day administration.

Indications

Encilor tablet provides fast, effective relief from the symptoms of seasonal allergic rhinitis, perennial allergic rhinitis and skin allergies including chronic urticaria. It is also effective in alleviating symptoms of allergic rhinitis such as sneezing, nasal discharge, itching, ocular itching and burning. Nasal and ocular sign and symptoms are relieved rapidly after oral administration. Encilor tablet is also indicated in idiopathic urticaria. In children over 2 years Encilor tablet is indicated for the symptomatic relief of seasonal allergic rhinitis and allergic skin conditions such as urticaria, nettlerash.

Dosage & Administration

Adults and children over 12 years of age : One Encilor tablet once daily. It is usually administered in the morning or when symptoms require treatment.
Children 2-12 years : Body weight over 30 kg one Encilor tablet once daily, below 30 kg, half Encilor tablet once daily.
Encilor tablet is not recommended for use below 2 years of age since safety and efficacy has not been established.

Side Effects

During controlled clinical studies the incidence of adverse events, including sedation and anticholinergic effects observed with 10 mg Loratadine was comparable to that observed with placebo. Studies on the effect of loratadine on actual driving performance, and on tests of cognitive and psychomotor functioning have shown it to be comparable to placebo.

Contraindications

Loratadine is contraindicated in patients who have shown hypersensitivity or idiosyncracy to their components.

Use in Pregnancy & Lactation

There is no experience of the use of Loratadine in human pregnancy. Therefore its use during pregnancy is not advisable. Loratadine is excreted in breast milk in a very small amount. So nursing mothers are advised not to take the drug.

Overdose

In adults somnolence, tachycardia and headache have been reported with overdose greater than 10 mg. Extrapyramidal signs and palpitations have been reported in children with over doses of greater than 10 mg. In the event of overdosage, general symptomatic and supportive measures should be instituted promptly and maintained for as long as necessary. It would seem reasonable to treat patients presenting early after large overdoses with oral activated charcoal. The conscious patients may be induced to vomit or gastric lavage may be performed.

Commercial Packaging

Encilor : Box containing 10 blister strips of 10 tablets.

Alervil......... (Pheniramine Maleate)

Alervil (Pheniramine Maleate)

Therapeutic Group: Anti Histamine

Alervil Syrup : Each 5 ml syrup contains Pheniramine Maleate BP 15 mg.

Descriptions

Alervil is suitable for the treatment of hypersensitivity reactions and pruritus of varying origin.

Indications

In different allergic conditions (hypersensitivity reactions) such as:



* Seasonal and perennial rhinitis;



* Hay fever (pollinosis) with attacks of sneezing, itching, running of the nose;



*Conjunctivitis;



* Different skin allergies like; dermatitis, eczema, urticaria, angioedema;



* Pruritus of various etiology;



* Vasomotor rhinitis;



* Vertigo.

Dosage & Administration

Alervil syrup is particularly suitable for children.
Children aged 1-3 years should receive half a measuring spoonful 2 or 3 times daily.
Children aged 4-12 years, 1 measuring spoonful 2 or 3 times daily.
Adults and young people 1-2 measuring spoonful of syrup 2 or 3 times a day after meals.
A daily dose of 3mg/kg body weight must not be exceeded.

Side Effects

Occasionally there may be drowsiness, gastrointestinal complaints, dryness of mouth, palpitation, urinary retention or hypersensitivity reactions. In isolated cases, higher doses may produce hallucinations, restlessness or confusion; in small children, agitation. In patients with narrow angle-glaucoma a rise in intraocular pressure is possible, which makes opthalmologic control necessary. Even if used according to prescription, these preparations may reduce alertness to such an extent that the ability to cope with street traffic or operate machinery is impaired.

Precautions

During pregnancy and lactation, pheniramine should be used only if strictly indicated,
and after considering the benefit/risk ratio for mother and child.

Contraindications

Hypersensitivity to pheniramine. Prostatic hypertrophy with residual urine formation.

Drug Interaction

The effect of drugs which act on the central nervous system (e.g. tranquilizers, sedatives, neuroleptic agents and MAO inhibitors) and of alcohol may be potentiated.

Commercial Packaging

Alervil syrup : Each glass bottle contains 75 ml syrup.

Fenofex (Fexofenadin)

Fenofex (Fexofenadin)

Therapeutic Group: Anti Histamine

((Fenofex: 60, 120,180mg and Each 5 ml suspension ))

1. Fenofex 60: Each film-coated tablet contains Fexofenadine Hydrochloride USP 60 mg 

2. Fenofex 120: Each film-coated tablet contains Fexofenadine Hydrochloride USP 120 mg

3. Fenofex 180: Each film-coated tablet contains Fexofenadine Hydrochloride USP 180 mg

4. Fenofex suspension: Each 5 ml suspension contains Fexofenadine Hydrochloride USP 30 mg