Ketorolac

    

                   Ketorolac

Generic Name: ketorolac (KEE-toe-ROLE-ak)
Brand Name: Toradol

Ketorolac is only intended for short-term (up to 5 days) treatment of moderately severe pain. It should not be used to treat minor or long-term pain. Do not use more of ketorolac than prescribed. Do not use ketorolac to treat children.

Ketorolac is a nonsteroidal anti-inflammatory drug (NSAID). It may cause an increased risk of serious and sometimes fatal heart and blood vessel problems (eg, heart attack, stroke). The risk may be greater if you already have heart problems or if you take ketorolac for a long time. Do not use ketorolac right before or after coronary artery bypass graft (CABG).

Ketorolac may cause an increased risk of serious and sometimes fatal stomach ulcers and bleeding. Elderly patients may be at greater risk. This may occur without warning signs.

Do not use ketorolac if:

• you are allergic to ketorolac, aspirin, or any other NSAIDs (eg, ibuprofen, celecoxib)
• you are taking aspirin or another NSAID (eg, ibuprofen, celecoxib)
• you are breast-feeding or are in labor
• you have recently had or will be having CABG
• you have a stomach ulcer or a history of ulcers or severe stomach problems (eg, bleeding, perforation)
• you have severe kidney problems or are at risk of kidney failure (eg, low blood volume, dehydrated)
• you have bleeding in the brain (eg, stroke, aneurysm) or bleeding problems (eg, platelet disorder, hemophilia), or you are at risk of bleeding

Do not use ketorolac to prevent pain before any major surgery.

Ketorolac is used for:

The short-term (up to 5 days) treatment of moderately severe pain (usually after surgery), alone or in combination with other medicines.

Ketorolac is an NSAID. Exactly how it works is not known. It may block certain substances in the body that are linked to inflammation. NSAIDs treat the symptoms of pain and inflammation. They do not treat the disease that causes these symptoms.

Do NOT use ketorolac if:

• you are allergic to any ingredient in ketorolac
• you have had a severe allergic reaction (eg, severe rash, hives, breathing difficulties, dizziness) to aspirin or an NSAID (eg, ibuprofen, naproxen, celecoxib)
• you are taking pentoxifylline, probenecid, aspirin, or another NSAID (eg, ibuprofen, celecoxib)
• you are in the last 3 months of pregnancy, are breast-feeding, or are in labor
• you have recently had or will be having CABG or you have a stomach ulcer or a history of ulcers or severe stomach problems (eg, bleeding, perforation)
• you have severe kidney problems or are at risk of kidney failure (eg, low blood volume, dehydrated)
• you have bleeding in the brain (eg, stroke, aneurysm) or bleeding problems (eg, platelet disorder, hemophilia), or you are at risk of bleeding
• you need to prevent pain before any major surgery

Contact your doctor or health care provider right away if any of these apply to you.

Before using ketorolac:

Some medical conditions may interact with ketorolac. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

• if you are pregnant, planning to become pregnant, or are breast-feeding
• if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
• if you have allergies to medicines, foods, or other substances
• if you have a history of kidney or liver problems, diabetes, or stomach or bowel problems (eg, bleeding, perforation, ulcers, Crohn disease)
• if you have a history of swelling or fluid buildup, asthma, growths in the nose (nasal polyps), or mouth inflammation
• if you have high blood pressure, blood disorders (eg, porphyria), bleeding or clotting problems, heart problems (eg, heart failure), or blood vessel disease, or you are at risk of any of these diseases
• if you have poor health, dehydration or low fluid volume, or low blood sodium levels, you smoke, drink alcohol, or have a history of alcohol abuse

Some MEDICINES MAY INTERACT with ketorolac. Tell your health care provider if you are taking any other medicines, especially any of the following:

• Anticoagulants (eg, warfarin), aspirin, clopidogrel, corticosteroids (eg, prednisone), heparin and other blood thinners (eg, dalteparin), pentoxifylline, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because the risk of bleeding may be increased
• Probenecid because it may increase the risk of ketorolac's side effects
• Cyclosporine, lithium, metformin, methotrexate, oral NSAIDs (eg, ibuprofen), or quinolones (eg, ciprofloxacin) because the risk of their side effects may be increased by ketorolac
• Angiotensin-converting enzyme (ACE) inhibitors (eg, enalapril) or diuretics (eg, furosemide, hydrochlorothiazide) because their effectiveness may be decreased by ketorolac

This may not be a complete list of all interactions that may occur. Ask your health care provider if ketorolac may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

Brand Name	Contains	Dosage Form	Manufacturer	Price(Tk.)
ACUPAIN	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Beacon Pharmaceuticals Ltd.	30s pack: 300.00 MRP
ACUPAIN	Ketorolac tromethamine 30mg/1ml ampoule	i.m/i.v Injection	Beacon Pharmaceuticals Ltd.	30mg (1ml) amp x 5s pack: 275.00 MRP
ANALAC	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Ziska Pharmaceuticals Ltd.	20s pack: 200.00 MRP
ANALAC	Ketorolac tromethamine 30mg/1ml ampoule	i.m/i.v Injection	Ziska Pharmaceuticals Ltd.	30mg (1ml) amp x 5s pack: 275.00 MRP
AROLAK	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Ambee Pharmaceuticals Ltd.	20s pack: 200.00 MRP
AROLAK	Ketorolac tromethamine 10mg/1ml ampoule & 30mg/1ml ampoule	i.m/i.v Injection	Ambee Pharmaceuticals Ltd.	10mg (1ml) amp x 5s pack: 150.00 MRP; 30mg (1ml) amp x 5s pack: 275.00 MRP
E-KET	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Edruc Limited	20s pack: 200.00 IP
E-KET	Ketorolac tromethamine 30mg/1ml ampoule	i.m/i.v Injection	Edruc Limited	30mg (1ml) amp x 5s pack: 250.00 MRP
EMODOL	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Jayson Pharmaceuticals Ltd.	20s pack: 200.00 IP
EMODOL	Ketorolac tromethamine 10mg/1ml ampoule & 30mg/1ml ampoule	i.m/i.v Injection	Jayson Pharmaceuticals Ltd.	10mg (1ml) amp x 10s pack: 331.30 IP; 30mg (1ml) amp x 5s pack: 250.00 IP; 30mg (1ml) amp x 10s pack: 556.30 IP
ETOLAC	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Ibn Sina Pharmaceutical Ind. Ltd.	20s pack: 200.00 MRP
ETOLAC	Ketorolac tromethamine 10mg/1ml ampoule & 30mg/1ml ampoule & 60mg/2ml ampoule	i.m/i.v Injection	Ibn Sina Pharmaceutical Ind. Ltd.	10mg (1ml) amp x 10s pack: 320.00 MRP; 30mg (1ml) amp x 10s pack: 550.00 MRP; 60mg (2ml) amp x 1s pack: 95.00 MRP
ETORAC	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Incepta Pharmaceuticals Ltd.	30s pack: 300.00 MRP
ETORAC	Ketorolac tromethamine 30mg/1ml ampoule & 60mg/1ml ampoule	i.m/i.v Injection	Incepta Pharmaceuticals Ltd.	30mg (1ml) amp x 1s pack: 55.00 MRP; 60mg (2ml) amp x 1s pack: 95.00 MRP
KELAC	Ketorolac tromethamine 10mg/tablet	Tablet	Chemist Laboratories Ltd.	20s pack: 160.00 MRP
KELAC	Ketorolac tromethamine 10mg/1ml ampoule & 30mg/1ml ampoule	i.m/i.v Injection	Chemist Laboratories Ltd.	10mg (1ml) amp x 5s pack: 125.00 MRP; 30mg (1ml) amp x 5s pack: 175.00 MRP
KENODOL	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Rangs Pharmaceuticals Ltd.	20s pack: 240.00 MRP
KENODOL	Ketorolac tromethamine 30mg/1ml ampoule	i.m/i.v Injection	Rangs Pharmaceuticals Ltd.	30mg (1ml) amp x 6s pack: 300.00 MRP
KEROLAC	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Gaco Pharmaceuticals	20s pack: 200.00 MRP
KETEKS	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	RAK Pharmaceuticals Pvt. Ltd.	30s pack: 300.00 MRP

Brand Name	Contains	Dosage Form	Manufacturer	Price(Tk.)
KETOBE 10	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Benham Pharmaceutical Ltd.	30s pack: 298.20 MRP
KETOFLEX	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Somatec Pharmaceutical Ltd.	20s pack: 200.00 MRP
KETONIC	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Eskayef Bangladesh Ltd.	20s pack: 200.00 MRP
KETONIC	Ketorolac tromethamine 10mg/1ml ampoule & 30mg/1ml ampoule	i.m/i.v Injection	Eskayef Bangladesh Ltd.	10mg (1ml) amp x 5s pack: 160.00 MRP; 30mg (1ml) amp x 5s pack: 275.00 MRP
KETORIN	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Orion Pharma Ltd.	20s pack: 200.00 MRP
KETORIN	Ketorolac tromethamine 30mg/1ml ampoule	i.m/i.v Injection	Orion Pharma Ltd.	30mg (1ml) amp x 5s pack: 250.00 MRP
KETROMIN	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Pacific Pharmaceuticals Ltd.	20s pack: 200.00 MRP
KFLAM	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Apex Pharmaceuticals Ltd.	20s pack: 120.00 MRP
KFLAM	Ketorolac tromethamine 30mg/1ml ampoule	i.m/i.v Injection	Apex Pharmaceuticals Ltd.	30mg (1ml) amp x 5s pack: 200.00 MRP
LOPADOL	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Popular Pharmaceuticals Ltd.	20s pack: 200.00 IP
LOPADOL	Ketorolac tromethamine 30mg/1ml ampoule	i.m/i.v Injection	Popular Pharmaceuticals Ltd.	30mg (1ml) amp x 5s pack: 250.00 IP
MINOLAC	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	ACI Ltd.	20s pack: 200.00 IP
MINOLAC	Ketorolac tromethamine 30mg/1ml ampoule	i.m/i.v Injection	ACI Ltd.	30mg (1ml) amp x 1s pack: 55.00 IP
OFPAIN	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Kemiko Pharmaceuticals Ltd.	20s pack: 200.00 MRP
OFPAIN	Ketorolac tromethamine 30mg/1ml ampoule	i.m/i.v Injection	Kemiko Pharmaceuticals Ltd.	30mg (1ml) amp x 1s pack: 50.00 MRP
ORADOL	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Aristopharma Ltd.	20s pack: 200.00 MRP
ORADOL	Ketorolac tromethamine 30mg/1ml ampoule & 60mg/1ml ampoule	i.m/i.v Injection	Aristopharma Ltd.	30mg (1ml) amp x 1s pack: 55.00 MRP; 60mg (2ml) amp x 1s pack: 95.00 MRP
ORC	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Navana Pharmaceuticals Ltd.	20s pack: 200.00 MRP
PAIR	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Drug International Ltd.	30s pack: 300.00 MRP
PAIR -30	Ketorolac tromethamine 30mg/1ml ampoule	i.m/i.v Injection	Drug International Ltd.	30mg (1ml) amp x 5s pack: 250.00 MRP

PERILAC	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Bio Pharma Laboratories Ltd.	20s pack: 200.00 MRP
PERILAC	Ketorolac tromethamine 10mg/1ml ampoule & 30mg/1ml ampoule	i.m/i.v Injection	Bio Pharma Laboratories Ltd.	10mg (1ml) amp x 5s pack: 150.00 MRP; 30mg (1ml) amp x 5s pack: 250.00 MRP
ROKET 10	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Globe Pharmaceuticals Ltd.	20s pack: 200.00 MRP
ROKET 30	Ketorolac tromethamine 30mg/1ml ampoule	i.m/i.v Injection	Globe Pharmaceuticals Ltd.	30mg (1ml) amp x 5s pack: 250.00 MRP
ROLAC	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Renata Limited	30s pack: 300.00 MRP
ROLAC	Ketorolac tromethamine 10mg/1ml ampoule & 30mg/1ml ampoule & 60mg/2ml ampoule	i.m/i.v Injection	Renata Limited	10mg (1ml) amp x 1s pack: 32.00 MRP; 30mg (1ml) amp x 1s pack: 55.00 MRP; 60mg (2ml) amp x 2s pack: 190.00 MRP
ROTEK	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Health Care Pharmaceuticals Ltd.	20s pack: 200.00 MRP
ROTEK	Ketorolac tromethamine 30mg/1ml ampoule	i.m/i.v Injection	Health Care Pharmaceuticals Ltd.	30mg (1ml) amp x 5s pack: 250.00 MRP
TODOL	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Opsonin Pharma Limited	30s pack: 300.00 MRP
TODOL	Ketorolac tromethamine 30mg/1ml ampoule & 60mg/1ml ampoule	i.m/i.v Injection	Opsonin Pharma Limited	30mg (1ml) amp x 5s pack: 280.00 MRP; 60mg (2ml) amp x 1s pack: 95.00 MRP
TOLEC	Ketorolac tromethamine USP 10mg/tablet	Tablet (film-coated)	Alco Pharma Ltd.	20s pack: 200.00 MRP
TORADOL	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Roche Bangladesh Pharmaceuticals Ltd.	20s pack: 460.20 MRP
TORAX	Ketorolac tromethamine 10mg/1ml ampoule & 30mg/1ml ampoule & 60mg/2ml ampoule	i.m/i.v Injection	Square Pharmaceuticals Ltd.	10mg (1ml) amp x 5s pack: 150.00 MRP; 30mg (1ml) amp x 5s pack: 275.00 MRP; 60mg (2ml) amp x 1s pack: 95.00 MRP
TORAX 10	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Square Pharmaceuticals Ltd.	30s pack: 300.00 MRP
TOROLAC	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Silva Pharmaceuticals Ltd.	20s pack: 200.00 MRP
WINOP	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Acme Laboratories Ltd.	20s pack: 200.00 MRP
WINOP	Ketorolac tromethamine 30mg/1ml ampoule & 60mg/1ml ampoule	i.m/i.v Injection	Acme Laboratories Ltd.	10mg (1ml) amp x 5s pack: 150.00 MRP; 30mg (1ml) amp x 1s pack: 50.00 MRP
XENOLAC-10	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Shamsul Alamin Pharmaceuticals Ltd.	20s pack: 200.00 MRP
XIDOLOC	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Beximco Pharmaceuticals Ltd.	20s pack: 200.00 IP
ZEPAC	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Novartis (Bangladesh) Ltd.	30s pack: 300.00 MRP

ZEPAC	Ketorolac tromethamine 30mg/1ml ampoule	i.m/i.v Injection	Novartis (Bangladesh) Ltd.	30mg (1ml) amp x 5s pack: 300.00 MRP
ZEROPAIN	Ketorolac tromethamine 10mg/tablet	Tablet (film-coated)	Health Care Pharmaceuticals Ltd.	20s pack: 240.00 MRP

For the Consumer

Applies to ketorolac: injectable, solution, tablet

Other dosage forms:

• nasal spray

In addition to its needed effects, some unwanted effects may be caused by ketorolac. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking ketorolac:

More common

• Swelling of face, fingers, lower legs, ankles, and/or feet
• weight gain (unusual)

Less common

• Bruising (not at place of injection)
• high blood pressure
• skin rash or itching
• small, red spots on skin
• sores, ulcers, or white spots on lips or in mouth

Rare

• Abdominal or stomach pain, cramping, or burning that is severe
• bleeding from the rectum or bloody or black, tarry stools
• bloody or cloudy urine
• blue lips and fingernails
• blurred vision of other vision change
• burning, red, tender, thick, scaly, or peeling skin
• chest pain
• convulsions
• cough or hoarseness
• dark urine
• decrease in amount of urine that is sudden
• fainting
• fast, irregular, noisy, or troubled breathing
• fever with severe headache, drowsiness, confusion, and stiff neck or back
• fever with or without chills or sore throat
• hallucinations (seeing, hearing, or feeling things that are not there)
• hearing loss
• hives
• increase in amount of urine or urinating often
• light-colored stools
• loss of appetite
• low blood pressure
• mood changes or unusual behavior
• muscle cramps or pain
• nausea, heartburn, or indigestion that is severe and continues
• nosebleeds
• pain in lower back and/or side
• pain, tenderness, or swelling in the upper stomach area
• painful or difficult urination
• pale skin
• puffiness or swelling of the eyelids or eyes
• ringing or buzzing in ears
• runny nose
• severe restlessness
• shortness of breath
• swollen or painful glands
• swollen tongue
• thirst that continues
• tightness in the chest with or without wheezing
• unusual tiredness or weakness
• vomiting of blood or material that looks like coffee grounds
• yellow eyes or skin

Some of the side effects that can occur with ketorolac may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common

• Abdominal or stomach pain (mild or moderate)
• bruising at place of injection
• diarrhea
• dizziness
• drowsiness
• headache
• indigestion
• nausea

Less common or rare

• Bloating or gas
• burning or pain at place of injection
• constipation
• feeling of fullness in abdominal or stomach area
• increased sweating
• vomiting

For Healthcare Professionals

Applies to ketorolac: injectable solution, nasal spray, oral tablet

Renal

Acute renal failure has been reported with short-term use of ketorolac, even with moderate doses. Hyperkalemia often accompanies acute renal failure. Chronic ketorolac exposure may result in transient increases in BUN and creatinine in 2% to 3% of patients. Renal papillary necrosis has also been reported after chronic ketorolac exposure in some animal studies.

Patients with preexisting renal disease, congestive heart failure, hypovolemia, hepatic cirrhosis, nephrotic syndrome, or hypoalbuminemia are at increased risk for acute renal failure during ketorolac therapy as renal function in these conditions is dependent upon renal prostaglandin synthesis. Risk versus benefit should be carefully weighed in such patients.

In addition, ketorolac may have renal-metabolic effects such as salt and water retention, inhibition of diuretic action, and hyperkalemia due to suppression of the renin-angiotensin-aldosterone system. These effects are similar to those reported with other nonsteroidal anti-inflammatory agents.

Renal failure associated with hemolytic uremic syndrome developed in a 58-year-old female treated for arthralgias with oral ketorolac. After a total dose of 30 mg the patient developed vomiting and bloody diarrhea. Three days later, the patient again developed nausea, vomiting, oliguria, facial and peripheral edema, and hypertension. Hemolytic anemia, thrombocytopenia, elevated lactate dehydrogenase, decreased fibrinogen, and renal failure were noted on laboratory evaluation. Treatment consisted of furosemide and supportive care. Eight days later, all laboratory values were within normal limits and the patient was well.

A case-control study suggested that patients who consumed 5000 or more pills containing NSAIDs during their lifetime may be at increased risk of end-stage renal disease.

Renal side effects have included acute renal failure and flank pain. Oliguria, nephritis, hyperkalemia, hematuria, proteinuria, and urinary frequency have also been reported. Ketorolac has also been implicated in a case of hemolytic uremic syndrome.

Gastrointestinal

As with other nonsteroidal anti-inflammatory agents, gastrointestinal complaints are common in patients on ketorolac therapy. While these effects are usually mild in nature, serious gastrointestinal effects are reported, including peptic and colonic ulceration and gastrointestinal bleeding and perforation. Serious gastrointestinal bleeding may not be preceded by symptoms. While experience is limited, there is some indication that the risk of serious gastrointestinal effects increases with prolonged treatment with ketorolac. Thus, ketorolac is only recommended for the short-term management of pain.

Patients with a history of serious gastrointestinal events or alcohol abuse are at increased risk for severe gastrointestinal side effects. Ketorolac should be used with caution in these patients.

Gastrointestinal side effects have included gastrointestinal pain (13%), nausea (12%), dyspepsia (12%), diarrhea, constipation, flatulence, stomatitis, rectal bleeding, and melena. More serious effects include peptic ulceration (including giant gastric and duodenal ulcers), and gastrointestinal bleeding and perforation. GI bleeding increased with larger doses, therapy duration longer than 5 days, and older patients. Pancreatitis and exacerbation of inflammatory bowel disease (ulcerative colitis, Crohn's disease) has also been reported.

Hematologic

Hematologic side effects have included purpura, thrombocytopenia, epistaxis, inhibition of platelet aggregation, increased bleeding time, leukopenia, and eosinophilia.

Hepatic

Hepatic side effects have included borderline increases in liver function tests in up to 15% of patients in clinical trials. However, significant increases (three times normal values) occur in less than 1% of patients. Hepatitis, liver failure, and cholestatic jaundice have been reported during postmarketing experience.

Respiratory

Respiratory side effects have included dyspnea, asthma, wheezing, and pulmonary edema.

Nervous system

Nervous system side effects have included headache (17%), somnolence or drowsiness (3% to 9%), dizziness (3% to 9%), convulsions, vertigo, tremors, hallucinations, and euphoria. In addition, paresthesias, stupor, and hyperkinesia are reported; causality is unknown.

Cardiovascular

Nonsteroidal anti-inflammatory drugs (NSAIDs) may elevate blood pressure and increase the risk for the initiation of antihypertensive therapy. Furthermore, NSAIDs may antagonize the blood pressure lowering effect of antihypertensive medications in patients already being treated with antihypertensive drugs.

Cardiovascular side effects have included edema, palpitations, vasodilation, hypotension, syncope, and pallor. In addition, blood pressure may be elevated by ketorolac which may have clinical relevance in patients with comorbid illnesses.

Dermatologic

Dermatologic side effects have included rash, pruritus, and urticaria. Exfoliative dermatitis has also been reported.

Hypersensitivity

Hypersensitivity side effects have included anaphylaxis, bronchospasm, acute angioedema (including laryngeal and tongue edema), and fever. Lyell's syndrome, erythema multiforme, bullous reactions such Stevens-Johnson syndrome, and toxic epidermal necrolysis have also been reported.

Local

Local side effects associated with intramuscular injection of ketorolac include local pain, ecchymosis, bruising, hematoma, and tingling.

Ocular

Ocular side effects have included altered or blurred vision in less than 1% of patients.

Psychiatric

Psychiatric side effects have included depression, insomnia, abnormal dreams, and nervousness.

Other

Other side effects have included rare reports of tinnitus and hearing loss. Weight gain during long-term ketorolac therapy has also been reported.