Amlodipine

COMMON BRAND NAME(S): Norvasc

GENERIC NAME(S): AMLODIPINE BESYLATE

Uses

Amlodipine is used with or without other medications to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidneyproblems. Amlodipine belongs to a class of drugs known as calcium channel blockers. It works by relaxing blood vessels so blood can flow more easily.

Amlodipine is also used to prevent certain types of chest pain (angina). It may help to increase your ability to exercise and decrease the frequency of angina attacks. It should not be used to treat attacks of chest pain when they occur. Use other medications (such as sublingual nitroglycerin) to relieve attacks of chest pain as directed by your doctor.

How to use amlodipine

Take this medication by mouth with or without food as directed by your doctor, usually once daily.

The dosage is based on your medical condition and response to treatment. Your doctor may gradually increase your dose. Follow your doctor's instructions carefully.

Use this medication regularly to get the most benefit from it. To help you remember, take it at the same time each day. It is important to continue taking this medication even if you feel well. Most people with high blood pressure do not feel sick.

If used for angina, this medication must be taken regularly to be effective. It should not be used to treat angina when it occurs. Use other medications (such as sublingual nitroglycerin) to relieve an angina attack as directed by your doctor. Consult your doctor or pharmacist for details.

Tell your doctor if your condition does not improve or if it worsens (for example, your blood pressure readings remain high or increase, chest pain continues or worsens).

Conditions

What conditions does amlodipine treat?

amlodipine oral is used to treat the following:

High Blood Pressure, Type of Angina Where Chest Pain Occurs at Rest, A Continuous Squeezing Pain in the Chest, Angina Pectoris Prevention

Side Effects

Dizziness, lightheadedness, swelling ankles/feet, or flushing may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

To lower your risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: fast/irregular/pounding heartbeat, fainting.

Although this medication is effective in preventing chest pain (angina), some people who already have severe heart disease may rarely develop worsening chest pain or a heart attack after starting this medication or increasing the dose. Get medical help right away if you experience: worsening chest pain, symptoms of a heart attack (such as chest/jaw/left arm pain, shortness of breath, unusual sweating).

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash,itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

List amlodipine side effects by likelihood and severity.

The following side effects are associated with amlodipine:

Common side effects of amlodipine:

• Fluid Retention in the Legs, Feet, Arms or HandsSevere
• Visible Water RetentionLess Severe

Infrequent side effects of amlodipine:

• DizzySevere
• Heart Throbbing or PoundingSevere
• DrowsinessLess Severe
• Feel Like Throwing UpLess Severe
• Low EnergyLess Severe
• Stomach CrampsLess Severe
• Temporary Redness of Face and NeckLess Severe

Rare side effects of amlodipine:

• Abnormal Heart RhythmSevere
• Abnormal Liver Function TestsSevere
• Abnormally Low Blood PressureSevere
• AnginaSevere
• Decreased Blood PlateletsSevere
• Decreased White Blood CellsSevere
• DepressionSevere
• Erythema MultiformeSevere
• Giant HivesSevere
• Heart AttackSevere
• Large Purple or Brown Skin BlotchesSevere
• Loss of One's Own Sense of Reality or IdentitySevere
• PancreatitisSevere
• Reaction due to an AllergySevere
• Slow HeartbeatSevere
• Yellowing of Skin or Eyes from Liver ProblemsSevere
• Abnormal DreamsLess Severe
• AnxiousLess Severe
• BackacheLess Severe
• Chronic Trouble SleepingLess Severe
• CrampsLess Severe
• DiarrheaLess Severe
• Difficulty SwallowingLess Severe
• Discolored Spots and Small Elevations of the SkinLess Severe
• Dry MouthLess Severe
• Excessive ThirstLess Severe
• Fast HeartbeatLess Severe
• Feeling RestlessLess Severe
• Feeling WeakLess Severe
• Frequent UrinationLess Severe
• GasLess Severe
• Hair LossLess Severe
• High Blood SugarLess Severe
• Incomplete or Infrequent Bowel MovementsLess Severe
• Involuntary QuiveringLess Severe
• ItchingLess Severe
• Loss of AppetiteLess Severe
• NervousLess Severe
• NosebleedLess Severe
• Not Feeling WellLess Severe
• NumbnessLess Severe
• Numbness and TinglingLess Severe
• Numbness, Tingling or Pain of Hands or FeetLess Severe
• Overgrowth of Gums Onto TeethLess Severe
• Pain in the EyeLess Severe
• Problems with EyesightLess Severe
• RashLess Severe
• Ringing in the EarsLess Severe
• Sensation of Spinning or WhirlingLess Severe
• Sexual ProblemsLess Severe
• Throwing UpLess Severe
• Trouble BreathingLess Severe
• Urination During the NightLess Severe
• Weight GainLess Severe
• Weight LossLess Severe

Precautions

Before taking amlodipine, tell your doctor or pharmacist if you are allergic to it; or to other dihydropyridine calcium channel blockers (such as nisoldipine, nifedipine) or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: a certain structural heart problem (aortic stenosis), very low blood pressure, liver disease.

This drug may make you dizzy. Do not drive, use machinery, or do any activity that requires alertness until you are sure you can perform such activities safely. Limitalcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Older adults may be more sensitive to the effects of this drug, especially dizziness.

During pregnancy, this medication should be used only when clearly needed. Discuss the risks and benefits with your doctor.

It is unknown if this drug passes into breast milk. Consult your doctor before breast-feeding.

What should I know regarding pregnancy, nursing and administering amlodipine to children or the elderly?

If you are:

Pregnant:

Only When Necessary: INSUFFICIENT HUMAN DATA AVAIL; NONTERATOGENIC EFFECTS OBSERVED IN ANIMALS

Nursing:

Precaution: INSUFFICIENT DATA AVAIL; CONSIDER MATERNAL TREATMENT BENEFIT VS INFANT RISK

An adult over 60:

Precaution: (SOM)DECR.CLR; INCR.SENSITIVITY:HYPOTENSION/CONSTIP./EDEMA

Giving amlodipine to a child under 12:

Warning: NO SAFETY AND EFFICACY DATA FOR AGE < 6 YEARS.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Check the labels on all your medicines (such as cough-and-cold products, diet aids, orNSAIDs such as ibuprofen, naproxen) because they may contain ingredients that could increase your blood pressure. Ask your pharmacist for more details.

Does amlodipine interact with other medications?

amlodipine may interact with the following medications:

Severe Interactions of amlodipine:

 

These medications are not usually taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

• AMLODIPINE/SIMVASTATIN (>20 MG)

Serious Interactions of amlodipine:

 

These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

• AMLODIPINE/CONIVAPTAN
• CALCIUM CHANNEL BLOCKERS/DANTROLENE
• SELECTED CALCIUM CHANNEL BLOCKERS/SELE
• 
  
• CTED MACROLIDES

Moderate Interactions of amlodipine:

 

These medications may cause some risk when taken together. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center. Symptoms of overdose may include: fainting, severe dizziness.

Notes

Do not share this medication with others.

Lifestyle changes that may help this medication work better include exercising, stopping smoking, reducing stress, and eating a low-cholesterol/low-fat diet. Consult your doctor for more details.

Laboratory and/or medical tests (such as blood pressure) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Check your blood pressure regularly while taking this medication. Learn how to monitor your own blood pressure at home, and share the results with your doctor.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature away from light and moisture. Storage temperature ranges differ according to different manufacturers, so consult your pharmacist for more information. Do not store in the bathroom. Keep all medications away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised March 2013. Copyright(c) 2013 First Databank, Inc.