Sleepil ...(( Eszopiclone ))

leepil (Eszopiclone)

Therapeutic Group: Antipsychotic, Neurotonic & Sedative

Generic: Eszopiclone

Presentation:

Sleepil 1 Tablet: Each tablet contains Eszopiclone INN 1 mg.
Sleepil 2 Tablet: Each tablet contains Eszopiclone INN 2 mg.

Pharmacology:

Eszopiclone is a non-benzodiazepine hypnotic that is a pyrrolpyrazine deriveative of the cyclospyrrolone class with a chemical structure unrelated to pyrasolopyrimidines, imidazopyridines, benzodiazepines, burbiturates or other drugs with known hypnotic properties. The precise mechanism of action of Eszopiclone as a hypnotic is unknown, but is effect is believed to result from its interaction with GABA-receptor complexes at binding domains located close to or allosterically coupled to benzodiazepines receptor.

Indication:

Sleepil is indicated for the treatment of both acute and long term insomenia.

Dosage & Administration:

Non-elderly adults: 2 mg immediately before bedtime.
Elderly patients: Starting dose for elderly patients whose primary complaint is difficulty falling asleep is 1 mg immediately before bedtime. The dose may be increased to 2 mg if clinically indicated. For elderly patients whose primary complaint is difficulty staying asleep, the recommended dose is 2 mg immediately before bedtime. 

Contraindications:

It is contraindicated in patients with depression, liver disease, asthma, bronchitis & respiratory disease.

Warning & Precautions:

Do not take this drug in the morning or not take 2 doses at once. Sleepil should be used with caution in patients with diseases or conditions that could affect metabolism or hemodynamic responses and to patients exhibiting signs and symptoms of depression.

Side Effects:

The most common side effects are drowsiness, dizziness, lightheadedness, difficulty with coordination, memory loss or amnesia.

Drug interaction:

Concomitant use of Eszopiclone with other CNS depressants including antihistamines, antidepressants, opioids, sedative or hypnotics & antipsychotics may increase the risk of CNS depression. Drugs that inhibit the CYP3A4 enzyme system, such as ketoconazole, itraconazole, clarithromycin, nefazodone, ritonavir, nelfinavir & rifampicin may reduce the effectiveness of Eszopiclone.

Use in Special group:

Use in pregnancy: Eszopiclone is a Pregnancy Category C drug. Therefore, it should not be used during pregnancy.
Use in lactation: Caution should be exercised when administered to a nursing mother. Premenopausal & menopausal women: It is helpful for the treatment of insomnia in premenopausal & menopausal women.
Use in paediatric: Safety and effectiveness in children have not been established.
Use in elderly patients: It is safe for elderly patients. 

Packing:

Sleepil 1 tablet: Each box contains 50's tablets in blister pack.
Sleepil 2 tablet: Each box contains 30's tablets in blister pack.