Myelin Vitamin B1, Vitamin B6 & Vitamin B12

Myelin

Vitamin B1, Vitamin B6 & Vitamin B12

Description

Myelin?  is a balanced combination of   Vitamin B1, Vitamin B6 and Vitamin B12, used mainly for several neurological  disorders.

Composition

Myelin? Tablet: Each film-coated tablet contains Thiamine Mononitrate BP 100 mg, Pyridoxine Hydrochloride BP 200 mg and Cyanocobalamin BP 0.2 mg.

Myelin? Injection: Each 3 ml ampoule contains Thiamine Hydrochloride BP 100 mg, Pyridoxine Hydrochloride BP 100 mg and Cyanocobalamin BP 1 mg.

Mode of action

Vitamin B1 converts carbohydrates, fatty acids and amino acids into energy, promotes healthy nerves, improves mood, strengthens the heart. Vitamin B6 forms RBCs, helps cells to make proteins, manufactures neurotransmitters e.g. serotonin and releases stored forms of energy, helps to prevent CVS diseases and stroke, helps to lift depression, eases insomnia. Vitamin B12 is essential for cell replication and important for RBC production, prevents anemia, helps to prevent depression, reduces nerve pain, numbness and tingling, lowers the risk of heart diseases.

Pharmacokinetics

The vitamin ingredients are absorbed well in per oral reception. Small amounts of thiamine are well absorbed from the GIT following oral administration. It is widely distributed to most tissues, and appears in breast milk. Within the cell, thiamine is mostly present as diphosphate. Thiamine is not stored to any appreciable extent in the body and amounts in excess of the body's requirements are excreted in the urine as unchanged thiamine or as metabolites. Pyridoxine, pyridoxal and pyridoxamine are readily absorbed from the GIT following oral administration and are converted to the active forms pyridoxal phosphate and pyridoxamine phosphate. They are stored mainly in liver where there is oxidation to 4-pyridoxic acid and other inactive metabolites, which are excreted in urine. As the dose increases, proportionally greater amounts are excreted unchanged in the urine. Pyridoxal crosses the placenta and is distributed in breast milk. Vitamin B12 substances bind to intrinsic factor, a glycoprotein secreted by the gastric mucosa and are then actively absorbed from the GIT. Absorption is impaired in patients with absence of intrinsic factor. Absorption from the GIT can also occur by passive diffusion. Vitamin B12 is extensively bound to specific plasma proteins called transcobalamins. Transcobalamin-II appears to be involved in the rapid transport of the cobalamins to tissues. It is stored in the liver, excreted in the bile and undergoes extensive enterohepatic recycling; part of a dose is excreted in the urine, most of it in the first 8 hours. Urinary excretion, however, accounts for only a small fraction in the reduction of total body stores acquired by dietary means. It diffuses across the placenta and also appears in breast milk.

Indications

Peripheral neuropathy/neuritis/neuralgia, myalgia, spinal pain, sciatica, lumbago.

Dosage & administration

Myelin? tablet is usually administered at a dose of 1 to 3 tablets per day or as directed by the physician. Myelin? injection is preferably injected intramuscularly (deep intragluteal). In severe cases, 1 ampoule daily until the acute symptoms subside. For milder cases and follow-up therapy, 2 to 3 ampoules per week.

Side effects

Generally well tolerated but allergic reactions may be observed in few cases.

Contraindications

Myelin? is contraindicated in patients on levodopa therapy, and in patients with hypersensitivity to any of the ingredients of the prepration.

Use in pregnancy & lactation : Myelin tablet is recommended.

Precautions

Cyanocobalamin should not be given before a diagnosis has been fully established because of the possibility of masking symptoms of subacute degeneration of the spinal cord. Cyanocobalamin is not suitable form of vitamin B12 for the treatment of optic neuropathies associated with raised plasma concentrations of cyanocobalamin.

Drug interactions

No drug interaction has been reported yet.

Overdosage

In the event of overdose, symptomatic and supportive treatment is recommended.

Storage

Store in a cool and dry place, protected from light.

Packaging

Myelin? Tablet: Each carton contains 10x5 tablets in blister pack.

Myelin? Injection: Each carton contains 5x1 ampoules in blister pack.