Pinor (Imipramine)

Pinor (Imipramine)

Therapeutic Group: Antipsychotic, Neurotonic & Sedative

Generic: Imipramine

Presentation:

Pinor Tablet: Each tablet contains Imipramine HCl USP 25 mg.

Pharmacology:

Imipramine is the prototype of the tricyclic class of antidepressants. It is a potent inhibitor of norepinephrine reuptake at noradrenergic nerve endings. It is also an inhibitor of 5-hydroxytrytamine (5-HT) reuptake but these effects are less marked than those on norepinephrine. Imipramine is a competitive antagonist at alfa-adrenoceptors but the effects are relatively weak.

Indication:

Treatment of depression, management of panic disorder, management of pain, management of enuresis, treatment of hyperactivity and attention deficit.

Dosage & Administration:

Depression: Initially up to 75 mg daily in divided doses increased gradually to 150-200 mg (up to 300 mg in hospital); up to 150 mg may be given as a single dose at bed time; Elderly: initially 10 mg daily, increased gradually to 30-50 mg daily; child not recommended for depression. Nocturnal enuresis: Child: 7 years, 25 mg; 8-11 years 25-50 mg, over 11 years, 50-75 mg at bedtime; max. period of treatment (Including gradual withdrawal) is 3 months;full physical examination is required before further course. Panic attack: Initially 10-25 mg/day, depending on how the medication is tolerated, raise the dose until the desired response is obtained. The daily doses required vary greatly from patient to patients, between 75-150 mg, if necessary it can be increased to 200 mg. Chronic painful condition: The dosage must be individualized (25-300 mg daily). A daily dose of 25-75 mg is generally sufficient.

Contraindications:

Recent myocardial infarction, arrhythmias (particularly heart block), not indicated in manic phase, severe liver disease.

Warning & Precautions:

Cardiac diseases (particularly with arrhythmias), history with epilepsy, pregnancy and breast feeding, elderly, hepatic impairment (avoid if severe), thyroid disease, psychoses, angle-closure glaucoma, history of urinary retention, concurrent electro-convulsive therapy.

Drowsiness may affect performances of skilled tasks (e.g. driving), alcohol induced Imipramine effect.

Side Effects:

Dry mouth, less sedation, blurred vision (disturbances of accommodation, increased intraocular pressure), constipation, nausea, difficulty with micturation; cardiovascular side-effects, sweating, tremors, rashes and hypersensitivity reaction (including urticaria & photosensitivity), behavioral disturbances (particularly in children) hypomania or mania (particularly in elderly), interference with sexual function; blood sugar changes, increased appetite, weight gain (occasionally weight loss).

Drug interaction:

Imipramine should not be used in combination with Monoamine oxidase inhibitors (MAO), anticholinergic agents, antihypertensive agents, methylphenidate, levodopa, antipsychotic drug, cimetidine, barbiturates, and oral contraceptives.

Packing:

Pinor Tablet: Each box contains 50's tablets in blister pack.