Piramax....... ( Piracetam )

Piramax (Piracetam) Therapeutic Group: Antipsychotic, Neurotonic & Sedative Generic: Piracetam Presentation: Piramax Tablet: Each film coated tablet contains Piracetam BP 800 mg. Pharmacology: Piracetam stimulates the cerebral cortex by increasing the rate of metabolism and the energy levels of neurons. It facilitates movement of information between the brain's two hemispheres via the corpus callosum, and improves the function of the neurotransmitter acetylcholine via muscarinic cholinergic (ACh) receptors which are implicated in memory processes. Furthermore, Piracetam may have an effect on NMDA glutamate receptors which are involved with learning and memory processes. Piracetam may exert its global effect on brain neurotransmission via modulation of ion channels (i.e. Ca2+, K+). Piracetam exerts its haemorrheological effects on the platelets, red blood cells and vessel walls by increasing erythrocyte deformability and by decreasing platelet aggregation, erythrocyte adhesion to vessel walls and capillary vasospasm. Indication: Piramax is indicated for cortical myoclonus, cerebral vascular disease, enhancing cognition & memory, dementia, dyslexia, slowing brain aging etc. Dosage & Administration: Adult: Initially 7.2 g daily in 2-3 divided doses, increased according to response by 4.8 g daily every 3-4 days up to maximum 20 g daily. In cerebro-cortical insufficiency disorders: The usual dose is 800 mg 3 times daily. In myoclonic seizures: Dose of 7.2 g daily, increasing by 4.8 g per day every 3 to 4 days up to maximum of 20 g daily, given in 2 or 3 divided doses. Aging disorder: 2.4 g to 4.8 g per day in divided doses. Children: 50 mg/kg of body weight in 3 divided doses. Contraindications: Piracetam is contraindicated in patients with severe renal impairment (renal creatinine clearance of less than 20 ml per minute), hepatic impairment, cerebral hemorrhage and in those with hypersensitivity to Piracetam or any of the excipients. Warning & Precautions: Abrupt discontinuation of treatment should be avoided as this may induce myoclonic or generalized seizures in some myoclonic patients. Side Effects: The side effects are vertigo, abdominal pain, diarrhea, nausea, vomiting, ataxia, insomnia, somnolence, agitation, anxiety, confusion, hallucination, angioneurotic edema, dermatitis and rash. Drug interaction: Confusion, irritability and sleep disorders were reported in concomitant use with thyroid extract (T3 + T4) Use in Special group: Use in Pregnancy: There are no adequate data from the use of Piracetam in pregnant women. Piracetam should not be used during pregnancy unless clearly necessary. Use in lactation: Piracetam l is excreted in human breast milk. Therefore, Piracetam should not be used during breastfeeding or breastfeeding should be discontinued, while receiving treatment with Piracetam. Use in Renal insufficiency: Piracetam is eliminated via the kidneys and care shoulds thus be taken in cases of renal insufficiency. Packing: Piramax Tablet: Each box contains 30's tablets in blister pack.